It was first identified by bast, knapp, and colleagues in 1981. I am a week out on having a 8 cm dermoid cyst removed through laparotomy. Ca125 is a high molecular weight glycoprotein which is raised in approximately 90% of patients with advanced epithelial ovarian cancer. Society of gynecologic oncology sog 44th annual meeting on womens cancer. My family has a strong history of ovarian cancer so my dr preformed the ca 125 test and it was in the normal range, but was told by my doctor that that is no assurance that you do have ovarian cancer it will take a biopsy to know for definite and most of the time that can be done laporoscopic which. Ca 125 levels of 35 uml strongly predicted extrauterine disease but lacked sensitivity in identifying patients needing staging. Hemminki k, zhang h, sundquist j, lorenzo bermejo j. Either a ca 125 level of 20 uml or a grade 3 tumor or both of these correctly identified 75% to 87% of patients.
Its an indication of cancer, but it is not totally accurate in identifying cancer. She also went through chemotherapy and by the end, her ca 125 was around 35. Muc16 is a member of the mucin family glycoproteins. The national comprehensive cancer network nccn, a notforprofit alliance of leading cancer centers devoted to patient care, research, and education, is dedicated to improving the quality, effectiveness, and efficiency of cancer care so that patients can live better lives. If a postmenopausal woman has a mass and an elevated ca125, she has an extremely high risk of having a cancer. Association of family risk and lifestylecomorbidities in.
About half of the women diagnosed with this type of cancer are 63 years or older. The cancer antigen 125 ca 125 blood test isnt recommended for women with an average risk of ovarian cancer. Modification of risk for subsequent cancer after female breast cancer by a family history of breast cancer. The prognostic value of serum ca 125 in patients with advanced ovarian carcinoma. Ca125 is expressed by fetal amniotic and coelomic epithelium. However, in younger women, ca125 is extraordinarily inaccurate. Measurement of preoperative ca 125 is a clinically useful test in endometrial cancer. Ca125 cancer antigen 125, carcinoma antigen 125, or carbohydrate antigen 125 also known as mucin 16 or muc16 is a protein that in humans is encoded by the muc16 gene. Monk j b, jerzog jt, kaye bs,krasner nc, vermorken bj, et al. After her 5th course of chemo with carboplatintaxol her ca125 was 2. The ca125 is a blood test that is often, but not always, elevated with ovarian cancer.